Product Name :
Oglufanide
CAS NO. :
38101-59-6
Formula :
C16H19N3O5
Molecular Weight::
333.34
Target:
VEGFR HCV Endogenous Metabolite
Serial Number:
Glu-Trp-OH
Short serial number :
EW
Purity:
95%
Description :
A naturally occurring thymic immunomodulator. EW in vivo regulates NK cell function independent of IFNγ but partly dependent on IL-12. Substrate for aminopeptidase W, Km 0.49 mM and kcat 5557 min⁻¹ .
References:
[1]. Bayes M, et al. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Jul-Aug;27(6):411-61. [2]. Nagendra Kumar Kaushik, et al. Biomedical importance of indoles. Molecules. 2013 Jun 6;18(6):6620-62. [3]. Noy A, et al. Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi’s sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team. J Clin Oncol. 2005 Feb 10;23(5):990-8. [4]. Smith DL, et al. Natural killer cell cytolytic activity is necessary for in vivo antitumor activity of the dipeptide L-glutamyl-L-tryptophan. Int J Cancer. 2003 Sep 10;106(4):528-533.
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