Calpain-1 Substrate | DNA_ Alkylatingdna-alkylating.com

Product Name :
Calpain-1 Substrate

CAS NO. :
1914987-47-5

Formula :
C62H97N17O16S1

Molecular Weight::
1368.60

Target:
others

Serial Number:
Glu(Edans)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(Dabcyl)-OH

Short serial number :
E(Edans)-PLFAER-K(Dabcyl)

Purity:
95%

Description :
Internally quenched substrate for calpain-1 (µ-calpain) with optimal cleavage motifs flanking the scissile bond. The enzyme showed a more than 18-fold higher turnover rate for the hydrolysis of this FRET substrate based on the amino acid sequence PLFAER than for EVYGMM a sequence derived from the cleavage site of the natural substrate α-spectrin.

References:
[1]. Jo H, et al. Development of α-helical calpain probes by mimicking a natural protein-protein interaction. J Am Chem Soc. 2012 Oct 24;134(42):17704-13.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: DNA_ Alkylatingdna

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