Product Name :
β-Amyloid (17-42)
CAS NO. :
155178-13-5
Formula :
C119H194N28O33S
Molecular Weight::
2577.1
Target:
Amyloid-β
Serial Number:
Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
Short serial number :
LVFFAEDVGSNKGAIIGLMVGGVVIA
Purity:
≥95%
Description :
Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer’s disease and cerebellar pre-amyloid in Down’s syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway.
References:
[1]. Wanli Wei, et al. Abeta 17-42 in Alzheimer’s disease activates JNK and caspase-8 leading to neuronal apoptosis. Brain. 2002 Sep;125(Pt 9):2036-43.
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