Product Name :
[Pro18, Asp21] β – Amyloid (17 – 21), iAb5
CAS NO. :
182912-74-9
Formula :
C33H43N5O8
Molecular Weight::
637.74
Target:
Amyloid-β
Serial Number:
Leu-Pro-Phe-Phe-Asp
Short serial number :
LPFFD
Purity:
≥95%
Description :
[Pro18, Asp21] β – Amyloid (17 – 21), iAb5 is a potent degrader of cerebral amyloid-beta (Abeta). Abeta deposition is associatied with the Alzheimer disease (AD), due to its related toxicity linked to its beta-sheet conformation and/or aggregation. β-Sheet Breaker Peptide iAβ5 reproducibly induces in vivo disassembly of fibrillar amyloid deposits. Thus, [Pro18, Asp21] β – Amyloid (17 – 21), iAb5 prevents and/or reverses neuronal shrinkage caused by Abeta, and reduces the extent of interleukin-1beta positive microglia-like cells that surround the Abeta deposits. β-Sheet Breaker Peptide iAβ5 reduces the size and/or number of cerebral amyloid plaques in AD. [Pro18, Asp21] β – Amyloid (17 – 21), iAb5 labeled by hydrophobic benzyl alcohol (HBA) tag, can be used for quantitative assay by showing vivid blue color under acidic conditions.
References:
[1]. Soto C, et al. Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer’s therapy. Nat Med. 1998 Jul;4(7):822-6. [2]. Sigurdsson EM, et al. In vivo reversal of amyloid-beta lesions in rat brain. J Neuropathol Exp Neurol. 2000 Jan;59(1):11-7. [3]. Okada Y, et al. Acid-Triggered Colorimetric Hydrophobic Benzyl Alcohols for Soluble Tag-Assisted Liquid-Phase Synthesis. Org Lett. 2015 Sep 4;17(17):4264-7.
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