FRET Substrates | DNA_ Alkylatingdna-alkylating.com

Product Name :
FRET Substrates

CAS NO. :
400716-78-1

Formula :
C94H146O23N24S1

Molecular Weight::
2012.38

Target:
Cathepsin

Serial Number:
Ac-Glu-Asp(Edans)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(Dabcyl)-Glu-NH2

Short serial number :
Ac-E-D(Edans)-KPILFFRLG-K(Dabcyl)-E-NH2

Purity:
95%

Description :
Ac-ED(edans)KPILFFRLGK(dabcyl)E-amide, a sensitive fluorescent (FRET) peptide substrate for cathepsin D. This enzyme can degrade extracellular matrix components and may facilitate the spread of tumor cells. High levels of active cathepsin D were found within senile plaques in brains of Alzheimer’s patients.

References:
[1]. Eketjäll S, et al. AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics. J Alzheimers Dis. 2016;50(4):1109-23.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: DNA_ Alkylatingdna

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