Product Name :
Angiotensin II (1-4), human
CAS NO. :
52580-29-7
Formula :
C24H37N7O8
Molecular Weight::
551.6
Target:
Angiotensin Receptor
Serial Number:
Asp-Arg-Val-Tyr
Short serial number :
DRVY
Purity:
≥95%
Description :
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na/H exchanger in the proximal tubules of the kidney++.
References:
[1]. De Giusti VC, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411. [2]. Moon JY, et al. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-5.
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