C-Myc Peptide epitope

Description :
c-Myc Peptide Trifluoroacetate is a synthetic peptide corresponding to the C-terminal amino acids (410-419) of human c-myc protein, and participates in regulation of growth-related gene transcription.c-Myc peptides are effective surrogates for c-Myc-tagged fusion proteins. In immunoassays, the c-Myc peptide can be used to bind to antibodies against c-Myc instead of the c-Myc-tagged fusion protein. The successful inhibition of antibody binding by the c-Myc peptide indicates that the binding effect is specific. c-Myc peptide is involved in the regulation of growth-related gene transcription processes. c-Myc polypeptide is a synthetic polypeptide corresponding to the 410-419 amino acid sequence of the C-terminus of the human c-Myc gene. c-Myc is a regulatory gene that encodes a transcription factor. c-Myc activation can produce many biological effects. The first effect to be found was to drive cell proliferation (by upregulating cyclin, downregulating p21). In addition, c-Myc also plays an important role in regulating cell growth (upregulating ribosomal RNA and protein), apoptosis (downregulating Bcl-2), differentiation, and stem cell self-renewal. c-Myc is a highly potent proto-oncogene, and upregulation of c-Myc has been found in a variety of cancers. Overexpression of c-Myc stimulates gene amplification, which may be achieved through DNA over-replication.