Product Name :
ACTH (6-24), human
CAS NO. :
33512-65-1
Formula :
C111H175N35O21
Molecular Weight::
2335.9
Target:
others
Serial Number:
His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro
Short serial number :
HFRWGKPVGKKRRPVKVYP
Purity:
≥95%
Description :
ACTH (6-24) (human) (Adrenocorticotropic hormone (6-24)) is an ACTH fragment. ACTH (6-24) (human) is a competitive inhibitor of steroidogenesis induced by ACTH (1-39) and ACTH (5-24) (Kd:13.4 and 3.4 nM). ACTH (6-24) (human) inhibits corticosterone production and cAMP accumulation induced by hPTH 1-34.
References:
[1]. Rafferty B, et al. Corticosteroidogenesis and adenosine 3′, 5′- monophosphate production by the amino-terminal (1-34) fragment of human parathyroid hormone in rat adrenocortical cells. Endocrinology. 1983 Sep;113(3):1036-42. [2]. Bristow AF, et al. Effects of ACTH (corticotropin) analogues on steroidogenesis and cyclic AMP in rat adrenocortical cells. Evidence for two different steroidogenically responsive receptors. Biochem J. 1980 Feb 15;186(2):599-603.
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