iRGD peptide | DNA_ Alkylatingdna-alkylating.com

Product Name :
iRGD peptide

CAS NO. :
1392278-76-0

Formula :
C35H57N13O14S2

Molecular Weight::
948.04

Target:
Integrin

Serial Number:
Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys-OH(Disulfide Bridge:Cys1-Cys9)

Short serial number :
YEQDPWGVKWWY

Purity:
95%

Description :
iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral transmission, and antitumor efficacy. Gene therapy.iRGD (CRGDKGPDC) (Disulfide bridge: C1-C9) is a 9-amino acid disulfide-bonded cyclic peptide that is formed by the oxidation of the first cysteine C to the c-sulfhydryl group at the end to form a disulfide bond. It can bind to integrin and enzymatically hydrolyze to produce CRGDK, and then interact with neuropilin-1 to promote tissue penetration of drugs, which has the effect of targeting tumors and tumor penetration.

References:
[1]. Puig-Saus C, et al. iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy. Gene Ther. 2014 Aug;21(8):767-74. [2]. Zhang L, et al. Combination of NRP1-mediated iRGD with 5-fluorouracil suppresses proliferation, migration and invasion of gastric cancer cells. Biomed Pharmacother. 2017 Sep;93:1136-1143.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: DNA_ Alkylatingdna

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