Product Name :
MPG
CAS NO. :
395069-92-8
Formula :
C126H201N35O33S1
Molecular Weight::
2766.22
Target:
Serial Number:
Gly-Ala-Leu-Phe-Leu-Gly-Phe-Leu-Gly-Ala-Ala-Gly-Ser-Thr-Met-Gly-Ala-Trp-Ser-Gln-Pro-Lys-Ser-Lys-Arg-Lys-Val-OH
Short serial number :
GALFLGFLGAAGSTMGAWSQPKSKRKV
Purity:
95%
Description :
MPG, HIV related is 27-aa peptide, derived from both the nuclear localisation sequence of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41 and is a potent delivery agent for the generalised delivery of nucleic acids and of oligonucleotides into cultured cells.It is a 27-residue peptide derived from the hydrophobic fusion peptide of HIV-1 gp41 (for efficient crossing of the cell membrane) and the hydrophilic nuclear localization sequence of SV40 large T antigen (for the nuclear addressing of the peptide). It contains a single mutation in which the second lysine in NLS has mutated to serine.
References:
[1]. Morris MC, et al. A novel potent strategy for gene delivery using a single peptide vector as a carrier. Nucleic Acids Res. 1999 Sep 1;27(17):3510-7.
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