Product Name :
cyclo(RGD-{DPhe}-K)
CAS NO. :
161552-03-0
Formula :
C27H41N9O7
Molecular Weight::
603.67
Target:
Integrin
Serial Number:
cyclo(Arg-Gly-Asp-DPhe-Lys)(main chain cyclo)
Short serial number :
cyclo(RGD-{DPhe}-K)
Purity:
95%
Description :
A very popular RGD cyclic peptide. c(RGDfK) is a 5-amino acid head-tailamide ring tumor-targeting peptide that specifically targets tumor microvessels and cancer cells by binding to αvβ3 integrin on the cell surface.There is a series of integrin isoforms that recognize and bind to the tripeptide sequence RGD (arginine-glycine-aspartate), representing the most prominent recognition motifs involved in cell adhesion. Among them, cyclo (-RGDfK) has been widely used in biomaterial coatings to improve cell adhesion or as a imaging agent for tumor treatment.
References:
[1]. Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95. [2]. Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14.
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