Product Name :
LGnRH-III, lamprey
CAS NO. :
147859-97-0
Formula :
C59H74N18O14
Molecular Weight::
1259.33
Target:
GnRH Receptor
Serial Number:
Pyr-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2
Short serial number :
Pyr-HWSHDWKPG-NH2
Purity:
95%
Description :
Lamprey GnRH (also called peforelin) is a highly potent and specific FSH-releasing peptide that may enhance fertility in animals and humans. The peptide has found application in stimulating FSH release in swine. Peforelin surpasses GnRH in suppressing the growth of MDA-MB-231 and MCF-7 breast cancer cells. In comparison to other GnRH-III analogs, the peptide exhibits a superior antitumor activity.LGnRH-III, lamprey acetate, a GnRH isoform isolated from the sea lamprey, is a weak GnRH receptor agonist with anti-tumor activity. It is an evolutionarily conserved member of the GnRH family and can stimulate the secretion of gonadotropins, luteinizing, and follicle-stimulating hormones.
References:
[1].Lamprey GnRH-III acts on its putative receptor via nitric oxide to release follicle-stimulating hormone specifically. [2]. Comparison of synthesis of 15 alpha-hydroxylated steroids in males of four North American lamprey species. [3].Is lGnRH-III the most potent GnRH analog containing only natural amino acids that specifically inhibits the growth of human breast cancer cells?. [4].Gonadotropin releasing hormone (GnRH) and gonadotropin inhibitory hormone (GnIH) in the songbird hippocampus: regional and sex differences in adult zebra finches.
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