Product Name :
CAP 232
CAS NO. :
147159-51-1
Formula :
C45H58N10O9S2
Molecular Weight::
947.13
Target:
Somatostatin Receptor
Serial Number:
DPhe-Cys-Tyr-DTrp-Lys-Cys-Thr-NH2(Disulfide Bridge:Cys2-Cys6)
Short serial number :
fCYwKCT-NH2(Disulfide Bridge:C2-C6)
Purity:
95%
Description :
TT-232 TFA is a somatostatin analog that acts as a peptide agonist for sst1/sst4 somatostatin receptors. TT-232 TFA inhibits tyrosine kinase activity in human colon tumor cell lines. TT-232 TFA was shown to suppress proliferation and induce apoptosis in a pancreatic tumor cell line.
References:
[1]. Szende B, et al. TT-232: a somatostatin structural derivative as a potent antitumor drug candidate. Anticancer Drugs. 2003 Sep;14(8):585-8. [2]. Kéri G, et al. A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12513-8. [3]. Tejeda M, et al. Growth inhibitory effect of the somatostatin structural derivative (TT-232) on leukemia models. Anticancer Res. 2005 Jan-Feb;25(1A):325-30. [4]. Pintér E, et al. Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia. Naunyn Schmiedebergs Arch Pharmacol. 2002 Aug;366(2):142-50. [Content Brief]
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