Product Name :
Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide
CAS NO. :
819048-44-7
Formula :
C51H70O11N18S2
Molecular Weight::
1175.35
Target:
Melanocortin Receptor
Serial Number:
Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide [D-Lys6] LH-RH CAS: 819048-44-7 序列:Ac-DArg-Cys-Glu-His-DPhe-Arg-Trp-Cys-NH2(Disulfide Bridge:Cys2-Cys8)
Short serial number :
Ac-rCEHfRWC-NH2(Disulfide Bridge:C2-C8)
Purity:
95%
Description :
Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide, a selective and highly potent β-MSH-derived melanocortin-4 receptor (MC-4R) agonist, has sub-nanomolar potency with the binding affinities of 0.55±0.06, 16.78±1.53, 56.79±4.66 and
References:
[1]. Doering SR, et al. Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput “Unbiased” Screening Campaign. J Med Chem. 2021 May 13;64(9):5577-5592. doi: 10.1021/acs.jmedchem.0c02041. Epub 2021 Apr 22. Erratum in: J Med Chem. 2023 May 25;66(10):7063-7065. [2].High-yield cell-free synthesis of human EGFR by IRES-mediated protein translation in a continuous exchange cell-free reaction format. [3].A2T and A2V Aβ peptides exhibit different aggregation kinetics, primary nucleation, morphology, structure, and LTP inhibition. [4]. Pathogenic Aβ A2V versus protective Aβ A2T mutation: Early stage aggregation and membrane interaction.
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