Product Name :
Magainin 1
CAS NO. :
108433-99-4
Formula :
C112H177N29O28S
Molecular Weight::
2409.9
Target:
Bacterial; Antibiotic; Fungal
Serial Number:
Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Gly-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Lys-Ser
Short serial number :
GIGKFLHSAGKFGKAFVGEIMKS
Purity:
≥95%
Description :
Magainins are peptide antibiotics with antibacterial and antiparasitic activities, originally extracted from the skin of Xenopus laevis. Magainin 1 and 2 are closely related peptides of 23 amino acids each and differ by two substitutions. These antimicrobial peptides have broad-spectrum, non-specific activity against a wide range of micro-organisms, including viruses, gram-positive and gram-negative bacteria, protozoa, yeasts and fungi, and may also be hemolytic and cytotoxic to cancer cells. Magainin 1 is a bactericide. Both Magainin 1 and 2 exhibit inhibitory action toward Herpes simplex virus type 1(HSV-1) and HSV-2.
References:
[1].Williams, RW. et al. Biophysical J. 53, 631A (1988); [2]. Morvan, A. et al. Mol. Mar. Biol. Biotechnol. 3, 327 (1994); [3].Matanic, A. et al. Int. J. Antimicrob Agents 23, 382 (2004); [4].Zasloff, M. Proc. Natl. Acad. Sci. 84, 5449 (1987).
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