Product Name :
IGF-I (1-3)
CAS NO. :
32302-76-4
Formula :
C12H19N3O6
Molecular Weight::
301.30
Target:
others
Serial Number:
Gly-Pro-Glu
Short serial number :
GPE
Purity:
≥95%
Description :
IGF-I (1-3) is a neuroactive peptide with a potent action on acetylcholine release. IGF-I (1-3)u is the N-terminal tripeptide of insulin-like growth factor-I. IGF-I (1-3) inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection
References:
[1]. Sara VR, et al. Identification of Gly-Pro-Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide. Biochem Biophys Res Commun. 1989 Dec 15;165(2):766-71. [2]. Aguado-Llera D, et al. Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex. Neuroreport. 2004 Aug 26;15(12):1979-82.
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