Product Name :
187-1, N-WASP inhibitor
CAS NO. :
380488-27-7
Formula :
C96H122N18O16
Molecular Weight::
1784.11
Target:
Arp2/3 Complex
Serial Number:
cyclo(Gln-Lys-DPhe-DPro-DPhe-Phe-DPro-Gln-Lys-DPhe-DPro-DPhe-Phe-DPro)(main chain cyclo)
Short serial number :
cyclo(QKfpfFpQKfpfFp)(main chain cyclo)
Purity:
95%
Description :
187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein.
References:
[1]. Peterson, et al. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10624-9. [2]. S Suetsugu, et al. Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J
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