Product Name :
Bax inhibitor peptide P5
CAS NO. :
579492-83-4
Formula :
C27H48N6O8S1
Molecular Weight::
616.77
Target:
Serial Number:
Pro-Met-Leu-Lys-Glu
Short serial number :
PMLKE
Purity:
95%
Description :
BIP P5 is a membrane-permeable peptide inhibitor of Bax translocation to mitochondria. In HeLa cells, BIP P5 protected cells from UVC- and STS-induced apoptosis. In U87-MG glioma cells, MCF-7 breast cancer cells and LNCaP prostate cancer cells, BIP P5 also inhibited apoptosis induced by anti-cancer drugs cisplatin, etoposide and doxorubicin. While BIP P5 did not suppress UVC- or STS-induced apoptosis in Bax-deficient cells (DU145), which suggested BIP P5 only suppressed Bax-mediated apoptosis. The caspase activation and the release of cytochrome c from mitochondria triggered by apoptotic stimuli were also significantly inhibited by BIP P5. BIP P5 inhibited the interaction of Ku70 and endogenous Bax in a dose-dependent way.
References:
[1]. Sawada M, Hayes P, Matsuyama S. Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70. Nat Cell Biol, 2003, 5(4): 352-357.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Phospho-Hormone sensitive lipase (Ser853) Antibody
Cathepsin D Antibody
SUMO1 Antibody (YA047): SUMO1 Antibody (YA047) is a non-conjugated and Rabbit origined monoclonal antibody, targeting to SUMO1. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.
