eight, e1.28. Osei-Hyiaman D, et al. (2008) Hepatic CB1 receptor is needed for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J Clin Invest 118(9):3160169. 29. Sampath H, Miyazaki M, Dobrzyn A, Ntambi JM (2007) Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J Biol Chem 282(4): 2483493. 30. Due A, et al. (2008) Comparison from the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control diets. Am J Clin Nutr 87(four):85562. 31. Marks KA, Kitson AP, Stark KD (2013) Hepatic and plasma sex differences in saturated and monounsaturated fatty acids are linked to variations in expression of elongase 6, but not stearoyl-CoA desaturase in Sprague-Dawley rats. Genes Nutr 8(three): 31727. 32. Fu S, et al. (2011) Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum tension in obesity. Nature 473(7348):52831. 33. Man WC, Miyazaki M, Chu K, Ntambi J (2006) Colocalization of SCD1 and DGAT2: Implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis. J Lipid Res 47(9):1928939. 34. Man WC, Miyazaki M, Chu K, Ntambi JM (2006) Membrane topology of mouse stearoyl-CoA desaturase 1. J Biol Chem 281(two):1251260. 35. Mileni M, et al. (2010) Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: Discovery of a deacylating water molecule and insight into enzyme inactivation. J Mol Biol 400(4):74354. 36. Kim YJ, Hernandez ML, Balla T (2013) Inositol lipid regulation of lipid transfer in specialized membrane domains. Trends Cell Biol 23(six):27078. 37. Grapov D, Adams SH, Pedersen TL, Garvey WT, Newman JW (2012) Type 2 diabetes associated modifications inside the plasma non-esterified fatty acids, oxylipins and endocannabinoids. PLoS One 7(11):e48852. 38. Jeong WI, et al. (2008) Paracrine activation of hepatic CB1 receptors by stellate cellderived endocannabinoids mediates alcoholic fatty liver. Cell Metab 7(three):22735. 39. Despr JP, Golay A, Sj tr L; Rimonabant in Obesity-Lipids Study Group (2005) Effects of rimonabant on metabolic danger elements in overweight individuals with dyslipidemia. N Engl J Med 353(20):2121134. 40. Hollister LE, Reaven GM (1974) Delta-9-tetrahydrocannabinol and glucose tolerance. Clin Pharmacol Ther 16(two):29702. 41. Rodondi N, Pletcher MJ, Liu K, Hulley SB, Sidney S; Coronary Artery Threat Development in Young Adults (CARDIA) Study (2006) Marijuana use, diet plan, body mass index, and cardiovascular danger factors (in the CARDIA study). Am J Cardiol 98(four):47884. 42. Muniyappa R, et al. (2013) Metabolic effects of chronic cannabis smoking. Diabetes Care 36(eight):2415422.ISRIB Technical Information 43.Ergosterol Description Hirvonen J, et al.PMID:23563799 (2012) Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic everyday cannabis smokers. Mol Psychiatry 17(6): 64249. 44. Zimmer A, Zimmer AM, Hohmann AG, Herkenham M, Bonner TI (1999) Improved mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci USA 96(ten):5780785. 45. Miyazaki M, Man WC, Ntambi JM (2001) Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. J Nutr 131(9):2260268. 46. Liu J, et al. (2003) Lipopolysaccharide induces anandamide synthesis in macrophages through CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of plateletactivating aspect.