A statistically significant association (p .according to Fisher’s exact test
A statistically significant association (p .as outlined by Fisher’s exact test) in between the presence of circumstances and colonisation by MAb positive Legionella strains (Table).One HCF (No) had no instances of legionellosis even though it was colonised by MAb positive Legionella strains.In contrast, one HCF (No) reported circumstances even though it was colonised by MAb damaging Legionella.No statistically considerable differences (p .according to Fisher’s exact test) were found within the occurrence of legionellosis for the HCFs colonised by MAb damaging L.pneumophila sg compared with those colonised by L.pneumophila sg (Table).This result suggests that there is absolutely no higher danger of infection HCFs in facilities colonised by L.pneumophila sg with no the virulence ssociated epitope recognised by MAb compared with these colonised by L.pneumophila sg .Moreover, we analysed the HCFs to ascertain regardless of whether the complexity of care (i.e.the casemix) was also a vital factor within the occurrence of legionellosis (Table).To this aim we merged the structures colonized by MAb negative L.pneumophila sg with those colonized by L.pneumophila sg .Analysis in the raw data (univariate evaluation) showed an association among the presence of MAb along with the presence of situations (p .by Fisher precise test).Together with the layering by a stratifying from the data we identified a statistically considerable association involving colonisation and reported instances only in the HCFs classified as CMI (p .in accordance with Fisher’s precise test).Discussion L.pneumophila sg is accountable for the majority of hospitalacquired infections.Some strains on the L.pneumophila sg population have an enhanced capability to cause illness the clinical predominance of L.pneumophila sg strains with certain genotypes suggests that they have the ability to result in infections in humansTable Legionellosis circumstances and colonisation with Legionella MAb good strainsHCFs with reported cases HCFs colonised with L.pneumophila sg MAb good HCFs colonised with L.pneumophila sg MAb adverse Total HCFs without having reported cases TotalHCFs without having Total reported instances p .in accordance with Fisher’s exact test.Ditommaso et al.BMC Infectious Ailments PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21332597 , www.biomedcentral.comPage ofTable Legionellosis instances in overall health care facilities colonised with L.pneumophila sg andor L.pneumophila sg MAb negativeHCFs with reported HCFs devoid of Total circumstances reported instances HCFs colonised with L.pneumophila sg MAb adverse HCFs colonised with L.pneumophila sg Totalp .in accordance with Fisher’s exact test..Amongst the L.pneumophila sg strains, some monoclonal subgroups (Knoxville, Philadelphia, Benidorm, FranceAllentown) show the virulenceassociated epitope recognised by MAb ; these strains appear to become related with hospital outbreaks, travelassociated infections or communityacquired infections .There are some published information [,,,,] around the serogroup and monoclonal subgroup distribution of L.pneumophila in XMU-MP-1 COA manmade water systems which are related or not associated with human disease.This paper describes the first Italian study in which information about the environmental distribution of strains in line with their MAb profile has been examined.This distribution was compared with all the occurrence of legionellosis.Our laboratory is involved within the environmental monitoring of several HCFs in Piemonte (location , km; population ,,); hence, we collected environmental strains from water systems in HCFs that are representative on the wider L.pneumophila population in our.
