Es, it falls within their responsibility, but treatment of the collected sewage is uncommon in upper-middle countries where sewerage coverage is relatively high [25]. Where on-site pit latrines and septic tanks are involved, their contents may reach watercourses TalmapimodMedChemExpress Talmapimod untreated because of improper disposal after emptying, system failure (e.g. of leach fields) or driven by factors such as flooding potentially exacerbated by climate change. In sanitation, provision is the dominant need (table 1), but there remain doubts over what form of provision can be extended to effect in the cities. It can be argued that in water and sanitation beneficial use of wastewater and excreta is the great scientific, technological and environmental challenge or opportunity of the coming Larotrectinib web quartercentury and is of special relevance to poor rapidly developing countries. There are doubts about the economic feasibility of classical sewerage and about its logic: to dilute excreta with precious water and then separate the two again is costly and energy-intensive. Ongoing experiments with dry or semi-wet sanitation will benefit from sophisticated microbiology but the challenge will be to go to scale at affordable cost and without making excessive demands upon users. In some developing countries, rapidly expanding urban peripheral areas include urban farming and market gardening using wastewater that may or may not have been treated. While there is clear evidence of communicable disease hazards for some workers and consumers [17], a full risk analysis of trade-offs may lead to better balancing of risks. The conservatism of utilities in this area is understandable especially in rich well-watered countries where the systems are wellestablished, but greater innovation may well benefit countries with water scarcity, and much greater scientific input is required. The value of sewage for irrigation is in terms of its water and plant nutrient content, particularly nitrogen and potassium (reducing eutrophication of freshwaters that would otherwise have received the effluent and fertilizer runoff), but industrial wastewater may contain high levels of toxic substances needing source-exclusion, removal or detoxification, a field for further research. The priority of downstream sanitation interventions is controversial; the two predominant but conflicting views are that the urgency of intra-household toilet provision overrides the need for full excreta management; or the lack of attention to excreta once it has left the household constitutes a major environmental and health problem. The former position rather neglects the fate of, for example, latrine pit contents, whereas the latter ignores the usual operational response which is to build treatment facilities that are costly to build and operate, rather than to improve transport and disposal of faecal sludge. Priorities and solutions are dependent upon residential population density, degree of industrialization and the options for faecal sludge disposal. The downstream risks encompass both health risks to neighbours and damage to the environment. Both require that faecal sludge be safely removed from the area. A comprehensive risk approach to the downstream aspects of sanitation after excreta leave the household has yet to be worked through and risk analysis has largely tackled specific questions at a single stage of one sector, and the overall strategy on a systems basis is less clear. It will need to involve other domains of water.Es, it falls within their responsibility, but treatment of the collected sewage is uncommon in upper-middle countries where sewerage coverage is relatively high [25]. Where on-site pit latrines and septic tanks are involved, their contents may reach watercourses untreated because of improper disposal after emptying, system failure (e.g. of leach fields) or driven by factors such as flooding potentially exacerbated by climate change. In sanitation, provision is the dominant need (table 1), but there remain doubts over what form of provision can be extended to effect in the cities. It can be argued that in water and sanitation beneficial use of wastewater and excreta is the great scientific, technological and environmental challenge or opportunity of the coming quartercentury and is of special relevance to poor rapidly developing countries. There are doubts about the economic feasibility of classical sewerage and about its logic: to dilute excreta with precious water and then separate the two again is costly and energy-intensive. Ongoing experiments with dry or semi-wet sanitation will benefit from sophisticated microbiology but the challenge will be to go to scale at affordable cost and without making excessive demands upon users. In some developing countries, rapidly expanding urban peripheral areas include urban farming and market gardening using wastewater that may or may not have been treated. While there is clear evidence of communicable disease hazards for some workers and consumers [17], a full risk analysis of trade-offs may lead to better balancing of risks. The conservatism of utilities in this area is understandable especially in rich well-watered countries where the systems are wellestablished, but greater innovation may well benefit countries with water scarcity, and much greater scientific input is required. The value of sewage for irrigation is in terms of its water and plant nutrient content, particularly nitrogen and potassium (reducing eutrophication of freshwaters that would otherwise have received the effluent and fertilizer runoff), but industrial wastewater may contain high levels of toxic substances needing source-exclusion, removal or detoxification, a field for further research. The priority of downstream sanitation interventions is controversial; the two predominant but conflicting views are that the urgency of intra-household toilet provision overrides the need for full excreta management; or the lack of attention to excreta once it has left the household constitutes a major environmental and health problem. The former position rather neglects the fate of, for example, latrine pit contents, whereas the latter ignores the usual operational response which is to build treatment facilities that are costly to build and operate, rather than to improve transport and disposal of faecal sludge. Priorities and solutions are dependent upon residential population density, degree of industrialization and the options for faecal sludge disposal. The downstream risks encompass both health risks to neighbours and damage to the environment. Both require that faecal sludge be safely removed from the area. A comprehensive risk approach to the downstream aspects of sanitation after excreta leave the household has yet to be worked through and risk analysis has largely tackled specific questions at a single stage of one sector, and the overall strategy on a systems basis is less clear. It will need to involve other domains of water.