Or biomarkers. Further, potential therapeutic implication of these phenotypes can now be examined in prospective trials. Future studies should also focus on establishing simple algorithms based on the most discriminant factors for assigning patients to specific phenotypes. Such algorithms will have to be tested in validation cohorts before they can be utilized in clinical practice.Supporting InformationText S1 Additional information on statistical analyses.(DOC)Table S1 Cluster analysis showing the relationships between continuous variables in 519 COPD subjects. (DOC) Table S2 Main characteristics of 22948146 the 527 COPD subjectsincluded in the cluster analysis, according to their cohort of recruitment (Leuven outpatient clinic and NELSON study). (DOC)Table SCorrelation matrix between variables used in the cluster analysis. (DOC)Table S4 Eigenvalues of the correlation matrix.(DOC)Table S5 Principal component analysis of 7 continuous variables in 527 patients: correlation coefficients between variables and components identified by principal component analysis. (DOC) Table S6 Relative contribution of the 17 dimensions identified in the multiple correspondence analyses. (DOC) Table S7 Correlations of the original categorical variables with the 17 dimensions derived from the multiple correspondence analyses. (DOC) Table S8 Comparison of included vs. excluded subjects from the cluster analysis. (DOC)Author ContributionsConceived and designed the experiments: PRB MD WJ. Performed the experiments: PRB JLP. Analyzed the data: PRB JLP BP DD NR JC TT MD WJ. Contributed reagents/materials/analysis tools: PRB JLP BP DD NR JC TT MD WJ. Wrote the paper: PRB JLP BP DD NR JC TT MD WJ.COPD Phenotypes at High Risk of Mortality
Liver cirrhosis is characterized by disturbances in the systemic circulation, including marked arterial vasodilation that occurs principally in the splanchnic circulation, reduces 
the total peripheral vascular resistance and arterial pressure, and causes a secondary increase in the AZ876 cardiac output. These abnormalities are central to the development of several major complications in patients with cirrhosis, such as the hepatorenal syndrome, ascites, spontaneous bacterial peritonitis, dilutional hyponatremia, and hepatopulmonary syndrome. Renal failure is the most clinically relevant condition among these 298690-60-5 conditions because its appearance generally indicates a very poor prognosis [1?0].We developed the MBRS scoring system, a simple prognostic model that includes determination of mean arterial pressure (MAP) and serum bilirubin level and 1516647 assessment of acute respiratory failure and sepsis. These 4 variables are to be analyzed on day 1 of admission to the intensive care unit (ICU). We used this model to analyze and predict the in-hospital mortality in 111 critically ill cirrhotic patients with acute kidney injury (AKI) [11]. The MBRS score [calculated using the following predictors: MAP, ,80 mmHg; serum bilirubin level, .80 mmol/L (4.7 mg/dl); acute respiratory failure, and sepsis] was defined as the sum of the values of the individual predictors, each value ranging from 0 to 4. This score 
has better discriminatory power than the other evaluation systems such as the Child-Pugh [12], model for endstage liver disease (MELD) [13], Acute Physiology and ChronicNew Score in Cirrhosis with AKIHealth Evaluation II and III (APACHE II III) [14,15], and sequential organ failure assessment (SOFA) system [16]. The area under the receiver operating characte.Or biomarkers. Further, potential therapeutic implication of these phenotypes can now be examined in prospective trials. Future studies should also focus on establishing simple algorithms based on the most discriminant factors for assigning patients to specific phenotypes. Such algorithms will have to be tested in validation cohorts before they can be utilized in clinical practice.Supporting InformationText S1 Additional information on statistical analyses.(DOC)Table S1 Cluster analysis showing the relationships between continuous variables in 519 COPD subjects. (DOC) Table S2 Main characteristics of 22948146 the 527 COPD subjectsincluded in the cluster analysis, according to their cohort of recruitment (Leuven outpatient clinic and NELSON study). (DOC)Table SCorrelation matrix between variables used in the cluster analysis. (DOC)Table S4 Eigenvalues of the correlation matrix.(DOC)Table S5 Principal component analysis of 7 continuous variables in 527 patients: correlation coefficients between variables and components identified by principal component analysis. (DOC) Table S6 Relative contribution of the 17 dimensions identified in the multiple correspondence analyses. (DOC) Table S7 Correlations of the original categorical variables with the 17 dimensions derived from the multiple correspondence analyses. (DOC) Table S8 Comparison of included vs. excluded subjects from the cluster analysis. (DOC)Author ContributionsConceived and designed the experiments: PRB MD WJ. Performed the experiments: PRB JLP. Analyzed the data: PRB JLP BP DD NR JC TT MD WJ. Contributed reagents/materials/analysis tools: PRB JLP BP DD NR JC TT MD WJ. Wrote the paper: PRB JLP BP DD NR JC TT MD WJ.COPD Phenotypes at High Risk of Mortality
Liver cirrhosis is characterized by disturbances in the systemic circulation, including marked arterial vasodilation that occurs principally in the splanchnic circulation, reduces the total peripheral vascular resistance and arterial pressure, and causes a secondary increase in the cardiac output. These abnormalities are central to the development of several major complications in patients with cirrhosis, such as the hepatorenal syndrome, ascites, spontaneous bacterial peritonitis, dilutional hyponatremia, and hepatopulmonary syndrome. Renal failure is the most clinically relevant condition among these conditions because its appearance generally indicates a very poor prognosis [1?0].We developed the MBRS scoring system, a simple prognostic model that includes determination of mean arterial pressure (MAP) and serum bilirubin level and 1516647 assessment of acute respiratory failure and sepsis. These 4 variables are to be analyzed on day 1 of admission to the intensive care unit (ICU). We used this model to analyze and predict the in-hospital mortality in 111 critically ill cirrhotic patients with acute kidney injury (AKI) [11]. The MBRS score [calculated using the following predictors: MAP, ,80 mmHg; serum bilirubin level, .80 mmol/L (4.7 mg/dl); acute respiratory failure, and sepsis] was defined as the sum of the values of the individual predictors, each value ranging from 0 to 4. This score has better discriminatory power than the other evaluation systems such as the Child-Pugh [12], model for endstage liver disease (MELD) [13], Acute Physiology and ChronicNew Score in Cirrhosis with AKIHealth Evaluation II and III (APACHE II III) [14,15], and sequential organ failure assessment (SOFA) system [16]. The area under the receiver operating characte.
