E method and cancer. J Pathol 226: 148157. two. Blanchet X, Langer M, Weber C, Koenen RR, von Hundelshausen P Touch of chemokines. Front Immunol three: 175. 3. Kakinuma T, Hwang ST CP21 biological activity Chemokines, chemokine receptors, and cancer metastasis. J Leukoc Biol 79: 639651. four. Baba M, Imai T, Nishimura M, Kakizaki M, Takagi S, et al. Identification of CCR6, the certain receptor to get a novel lymphocyte-directed CC chemokine LARC. J Biol Chem 272: 1489314898. 5. Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, et al. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints by means of CCL20 in rheumatoid arthritis and its animal model. J Exp Med 204: 2803 2812. six. Reboldi A, Coisne C, Baumjohann D, Benvenuto F, 
Bottinelli D, et al. CC chemokine receptor 6-regulated entry of TH-17 cells in to the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 10: 514 523. 7. Yamazaki T, Yang XO, Chung Y, Fukunaga A, Nurieva R, et al. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol 181: 83918401. eight. Harper EG, Guo C, Rizzo H, Lillis JV, Kurtz SE, et al. Th17 GNF-7 site cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J Invest Dermatol 129: 21752183. 9. Kaser A, Ludwiczek O, Holzmann S, Moschen AR, Weiss G, et al. Elevated expression of CCL20 in human inflammatory bowel disease. J Clin Immunol 24: 7485. 10. Chae WJ, Gibson TF, Zelterman D, Hao L, Henegariu O, et al. Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis. Proc Natl Acad Sci U S A 107: 55405544. 11. Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, et al. Adenoma-linked barrier defects and microbial merchandise drive IL-23/IL-17mediated tumour development. Nature 491: 254258. 12. Baltgalvis KA, Berger FG, Pena MM, Davis JM, Muga SJ, et al. Interleukin-6 and cachexia in ApcMin/+ mice. Am J Physiol Regul Integr Comp Physiol 294: R393401. 13. Rao VP, Poutahidis T, Ge Z, Nambiar PR, Horwitz BH, et al. Proinflammatory CD4+ CD45RB lymphocytes market mammary and intestinal carcinogenesis in Apc mice. Cancer Res 66: 5761. 14. Tosolini M, Kirilovsky A, Mlecnik B, Fredriksen T, Mauger S, et al. Clinical influence of distinct classes of infiltrating T cytotoxic and helper cells in individuals with colorectal cancer. Cancer Res 71: 1263 1271. 15. Rakoff-Nahoum S, Medzhitov R Regulation of spontaneous intestinal tumorigenesis by way of the adaptor protein MyD88. Science 317: 124127. 16. Rubie C, Oliveira V, Kempf K, Wagner M, Tilton B, et al. Involvement of chemokine receptor CCR6 in colorectal cancer metastasis. Tumour Biol 27: 166174. 17. Kirshberg S, Izhar U, Amir G, Demma J, Vernea F, et al. Involvement of CCR6/CCL20/IL-17 axis in NSCLC illness progression. PLoS One six: e24856. 18. Ghadjar P, Loddenkemper C, Coupland SE, Stroux A, Noutsias M, et al. Chemokine receptor CCR6 expression level 25837696 and aggressiveness of prostate cancer. J Cancer Res Clin Oncol 134: 11811189. 9 CCL20-CCR6 Interactions Market Spontaneous Intestinal Tumorigensis 19. Frick VO, Rubie C, Kolsch K, Wagner M, Ghadjar P, et al. CCR6/ CCL20 chemokine expression profile in distinct colorectal malignancies. Scand J Immunol 78: 298305. 20. Dellacasagrande J, Schreurs OJ, Hofgaard PO, Omholt H, Steinsvoll S, et al. Liver metastasis of cancer facilitated by chemokine receptor CCR6. Scand J Immunol 57: 534544. 21. Ghadjar P, Coupland SE, Na IK, Noutsias M, Letsch A, et al. Chemokine receptor CCR6 express.E system and cancer. J Pathol 226: 148157. two. Blanchet X, Langer M, Weber C, Koenen RR, von Hundelshausen P Touch of chemokines. Front Immunol three: 175. 3. Kakinuma T, Hwang ST Chemokines, chemokine receptors, and cancer metastasis. J Leukoc Biol 79: 639651. four. Baba M, Imai T, Nishimura M, Kakizaki M, Takagi S, et al. Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J Biol Chem 272: 1489314898. 5. Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, et al. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints by way of CCL20 in rheumatoid arthritis and its animal model. J Exp Med 204: 2803 2812. six. Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, et al. CC chemokine receptor 6-regulated entry of TH-17 cells into the CNS by means of the choroid plexus is necessary for the initiation of EAE. Nat Immunol 10: 514 523. 7. Yamazaki T, Yang XO, Chung Y, Fukunaga A, Nurieva R, et al. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol 181: 83918401. eight. Harper EG, Guo C, Rizzo H, Lillis JV, Kurtz SE, et al. Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J Invest Dermatol 129: 21752183. 9. Kaser A, Ludwiczek O, Holzmann S, Moschen AR, Weiss G, et al. Enhanced expression of CCL20 in human inflammatory bowel disease. J Clin Immunol 24: 7485. ten. Chae WJ, Gibson TF, Zelterman D, Hao L, Henegariu O, et al. Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis. Proc Natl Acad Sci U S A 107: 55405544. 11. Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, et al. Adenoma-linked barrier defects and microbial items drive IL-23/IL-17mediated tumour development. Nature 491: 254258. 12. Baltgalvis KA, Berger FG, Pena MM, Davis JM, Muga SJ, et al. Interleukin-6 and cachexia in ApcMin/+ mice. Am J Physiol Regul Integr Comp Physiol 294: R393401. 13. Rao VP, Poutahidis T, Ge Z, Nambiar PR, Horwitz BH, et al. Proinflammatory CD4+ CD45RB lymphocytes promote mammary and intestinal carcinogenesis in Apc mice. Cancer Res 66: 5761. 14. Tosolini M, Kirilovsky A, Mlecnik B, Fredriksen T, Mauger S, et al. Clinical effect of diverse classes of infiltrating T cytotoxic and helper cells in individuals with colorectal cancer. Cancer Res 71: 1263 1271. 15. Rakoff-Nahoum S, Medzhitov R Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317: 124127. 16. Rubie C, Oliveira V, Kempf K, Wagner M, Tilton B, et al. Involvement of chemokine receptor CCR6 in colorectal cancer metastasis. Tumour Biol 27: 166174. 17. Kirshberg S, Izhar U, Amir G, Demma J, Vernea F, et al. Involvement of CCR6/CCL20/IL-17 axis in NSCLC illness progression. PLoS A single six: e24856. 18. Ghadjar P, Loddenkemper C, Coupland SE, Stroux A, Noutsias M, et al. Chemokine receptor CCR6 expression level 25837696 and aggressiveness of prostate cancer. J Cancer Res Clin Oncol 134: 11811189. 9 CCL20-CCR6 Interactions Market Spontaneous Intestinal Tumorigensis 19. Frick VO, Rubie C, Kolsch 
K, Wagner M, Ghadjar P, et al. CCR6/ CCL20 chemokine expression profile in distinct colorectal malignancies. Scand J Immunol 78: 298305. 20. Dellacasagrande J, Schreurs OJ, Hofgaard PO, Omholt H, Steinsvoll S, et al. Liver metastasis of cancer facilitated by chemokine receptor CCR6. Scand J Immunol 57: 534544. 21. Ghadjar P, Coupland SE, Na IK, Noutsias M, Letsch A, et al. Chemokine receptor CCR6 express.
