Product Name: TH588
Chemical Name: N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine
SMILES Code: NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC3CC3)=N1
CAS NO: 1867-73-8 Product: GSK-J2
Synonym: TH-588; TH 588
Chemical Formula: C13H12Cl2N4
Appearance: Solid powderMedchemexpress.com
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).mGluR inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: TH588 is a potent inhibitor of human 7,8-Dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1) with an IC50 value of 5 nM and good metabolic stability. Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNPubMed ID:http://bloodjournal.hematologylibrary.org/content/21/1/102.short
