Product Name: Salinosporamide A
Chemical Name: (1R,4R,5S)-4-(2-chloroethyl)-1-[(S)-(1S)-2-cyclohexen-1-ylhydroxymethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
SMILES Code: O=C1[C@H](CCCl)[C@]([C@@]2([C@@H](O)[C@@]3([H])CCCC=C3)N1)(C)OC2=O
CAS NO: 28371-16-6 Product: PF-06380101
Synonym: NPI-0052; Marizomib; ML-858
Chemical Formula: C15H20ClNO4
Appearance: Solid powderWeb Site click
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).Ras inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: Salinosporamide A (NPI-0052, ML-858, Marizomib) is a novel inhibitor of marine derived proteasome which inhibits CT-L, C-L, and T-L proteasome activities in human erythrocyte-derived 20S proteasomes with EC50 values of 3.5 nM, 430 nM, 28 nM, respectively.PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22409268
