Product Name: SIS3 hydrochloride
Chemical Name: 1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one;hydrochloride
SMILES Code: CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl
CAS NO: 92562-88-4 Product: PEPA
Synonym: SIS 3; SIS-3
Chemical Formula: C28H28ClN3O3
Appearance: Solid powderWeb Site click
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).Raf inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: SIS3 is a novel specific inhibitor of Smad3, which inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways.PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18222647
