Product Name: Ruboxistaurin
Chemical Name: (12E,32E,7S)-7-((dimethylamino)methyl)-22,25-dihydro-11H,21H,31H-6-oxa-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione
SMILES Code: O=C1NC(C(C2=CN(C3=CC=CC=C32)CCO[C@H](CN(C)C)CC4)=C1C5=CN4C6=CC=CC=C56)=O
CAS NO: 1597403-47-8 Product: EX-527 (R-enantiomer)
Synonym: LY-333531; LY333531; LY 333531
Chemical Formula: C28H28N4O3
Appearance: Solid powderMedchemexpress
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).CETP inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: Ruboxistaurin (LY-333531) is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin reduces oxidatPubMed ID:http://www.ncbi.nlm.nih.gov/pubmed?term=17135248
