Product Name: ONO-4059
Chemical Name: (R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one
SMILES Code: O=C1N(C2=CC=C(C=C2)OC3=CC=CC=C3)C4=C(N)N=CN=C4N1[C@H]5CN(C(C#CC)=O)CC5
CAS NO: 244240-24-2 Product: Pseudobufarenogin
Synonym: ONO4059; ONO 4059; GS4059; GS 4059; GS-4059; Tirabrutinib
Chemical Formula: C25H22N6O3
Appearance: Solid powderMedchemexpress.com
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).Drug-Linker Conjugates for ADC inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: ONO-4059 is a potent and orally active Bruton agammaglobulinemia tyrosine kinase (BTK) in hibitor. Upon administration, ONO-4059 covalently binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22177955
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Product Name: ONO-4059
Chemical Name: (S)-9-(1-acryloylpiperidin-3-yl)-6-amino-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one
SMILES Code: O=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[C@@H]5CN(C(C=C)=O)CCC5
CAS NO: 1449685-96-4 Product: Amifampridine
Synonym: ONO4059; ONO 4059; GS 4059; GS-4059; GS4059
Chemical Formula: C25H24N6O3
Appearance: Solid powderMedchemexpress
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).Aldose Reductase inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: ONO-4059 is an orally available formulation containing an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, ONO-4059 covalently binds to BTK within B cells, thereby preventing B cellPubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22207485