Product Name: NMS-873
Chemical Name: 3-(3-(cyclopentylthio)-5-(((2-methyl-4′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)oxy)methyl)-4H-1,2,4-triazol-4-yl)pyridine
SMILES Code: O=S(C1=CC=C(C2=CC=C(OCC3=NN=C(SC4CCCC4)N3C5=CC=CN=C5)C=C2C)C=C1)(C)=O
CAS NO: 1133432-49-1 Product: GSK2141795
Synonym: NMS873; NMS 873
Chemical Formula: C27H28N4O3S2
Appearance: Solid powderWeb Site click
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).Btk inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: NMS-873 is a potent, allosteric and specific VCP inhibitor with IC50 of 30 nM. NMS-873 activated the unfolded protein response, interfered with autophagy and induced cancer cell death. The consistent pattern of cancer cell killing by covalent and allosterPubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/17337266
