Product Name: LOXO-101 sulfate
Chemical Name: (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide;sulfuric acid
SMILES Code: C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F.OS(=O)(=O)O
CAS NO: 1415-73-2 Product: GSK-5498A
Synonym: LOXO101 sulfate; LOXO 101 sulfate; Larotrectinib sulfate
Chemical Formula: C21H24F2N6O6S
Appearance: Solid powderMedchemexpress
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).MyD88 inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: LOXO-101 is a small molecule that was designed to block the ATP binding site of the TRK family of receptors, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases.PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/17041621
