Product Name: Echinomycin
Chemical Name: N-(2-quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-(8→1)-lactone,cyclic (3→7)-thioether-L-valine
SMILES Code: O=C(NC(COC(C(C(C)C)N(C)C(C1CS2)=O)=O)C(NC(C)C(N(C(C2SC)C(N(C)C(C(OCC(NC(C3=NC(C=CC=C4)=C4N=C3)=O)C(NC(C(N1C)=O)C)=O)=O)C(C)C)=O)C)=O)=O)C5=NC6=C(N=C5)C=CC=C6
CAS NO: 784210-88-4 Product: AVN-944
Synonym: Antibiotic A 654I; NSC 13502; NSC 526417; Quinomycin A; SK 302B
Chemical Formula: C51H64N12O12S2
Appearance: Solid powderWeb Site click
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).Histone_Modification_Research_Compound_Library inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: Echinomycin (Antibiotic A 654I; NSC 13502; NSC 526417; Quinomycin A; SK 302B) is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. InhibPubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/12432547
