Product Name: CGI1746
Chemical Name: 4-(tert-butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)benzamide
SMILES Code: O=C(NC1=CC=CC(C(N=C2NC3=CC=C(C(N4CCOCC4)=O)C=C3)=CN(C)C2=O)=C1C)C5=CC=C(C(C)(C)C)C=C5
CAS NO: 199666-03-0 Product: GNE-9605
Synonym: CGI-1746; CGI 1746
Chemical Formula: C34H37N5O4
Appearance: Solid powderMedchemexpress
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).Epigenetic Reader Domain inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: CGI1746 is a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation, which has exquisite selectivity for Btk and inhibits both auto- and transphosphorylation steps necessary for enzPubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21533169
