Product Name: BGB-324
Chemical Name: (S)-1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine
SMILES Code: NC1=NC(NC2=CC=C3C(CC[C@@H](N4CCCC4)CC3)=C2)=NN1C5=NN=C6C(CCCC7=CC=CC=C76)=C5
CAS NO: 123464-89-1 Product: Tipifarnib (S enantiomer)
Synonym: R428; R-428; R 428; BGB324; BGB-324; BGB 324
Chemical Formula: C30H34N8
Appearance: Solid powderMedchemexpress.com
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).CGRP Receptor inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: BGB-324 (R428) is a potent and selective small-molecule inhibitor(IC50=14 nM), blocks the activities of Axl. which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may plaPubMed ID:http://www.nature.com/nm/journal/v14/n12/full/nm.1888.html
