Product Name: AST487
Chemical Name: 1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea
SMILES Code: O=C(NC1=CC=C(OC2=NC=NC(NC)=C2)C=C1)NC3=CC=C(CN4CCN(CC)CC4)C(C(F)(F)F)=C3
CAS NO: 141977-79-9 Product: Dihydrochelerythrine
Synonym: NVPAST487; AST 487; AST-487
Chemical Formula: C26H30F3N7O2
Appearance: Solid powderWeb Site click
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).Reverse Transcriptase inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: AST487 (NVP-AST487) is a RET kinase inhibitor/FLT3 inhibitor. The RET kinase has emerged as a promising target for the therapy of medullary thyroid cancers (MTC) and of a subset of papillary thyroid cancers. NVP- AST487 has an IC(50) of 0.88 mumol/L on REPubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22225917
