Product Name: 2’3′-cGAMP
Chemical Name: 2-Amino-9-((5R,7R,8R,12aR,14R,15R,15aS,16R)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxy-2,10-dioxidooctahydro-12H-5,8-methanofuro(3,2-l)(1,3,6,9,11,2,10)pentaoxadiphosphacyclotetradecin-7-yl)-1,9-dihydro-6H-purin-6-one
SMILES Code: O=P1(O)O[C@]([C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O4)([H])[C@@]4([H])COP(O[C@@]5([H])[C@H](N6C=NC7=C6NC(N)=NC7=O)O[C@]([C@H]5O)([H])CO1)(O)=O
CAS NO: 153587-01-0 Product: INCB 3284
Synonym: Guanosine-Adenosine 2′,3′-cyclic monophosphate; 2′-3′-Cyclic GMP-AMP
Chemical Formula: C20H24N10O13P2
Appearance: Solid powderWeb Site:Medchemexpress
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).Elastase inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: 2’3’-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA. It binds tightly to the adapter protein STING (stimulator of interferon genes) with a Kd value oPubMed ID:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC551494/?tool=pmcentrez