Product Name: PF-299804 (Dacomitinib) | HER1/2/3 inhibitor
Product Description: PF299804 (Dacomitinib) is an orally-available, aminoquinazoline-based, irreversible pan-HER inhibitor with IC50s of 6, 46, and 74 nM for ErbB1, ErbB2, and ErbB4, respectively. PF299804 inhibits ErbB1 autophosphorylation in A431 cells with an IC50 of 15 nMMedchemexpress
Chemical Formula: C24H25ClFN5O2
Molecular Weight: 469.94
‘&“CAS NO: 1221186-53-3 TEPP-46
Purity: 99%
Appearance: White
Chemical Name: (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamideLeukotriene Receptor inhibitors
Solubility: Up to 50 mM in DMSO
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage Condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.PubMed ID:http://dmd.aspetjournals.org/content/36/9/1846.long
