Product Name: GW4064 | non-steroidal FXR agonist
Product Description: GW4064 is a potent, orally-available, non-steroidal, isoxazole-based agonist of FXR with an EC50 of 15 nM. In a Fisher rat model, GW4064 was found to lower serum triglyceride levels in a dose-dependent manner and an ED50 of 20 mg/kg. (1)In C57BL/6 mice, GMedchemexpress
Chemical Formula: C28H22Cl3NO4
Molecular Weight: 542.84
‘&“CAS NO: 867160-71-2 Linsitinib
Purity: 98%
Appearance: white
Chemical Name: (E)-3-(2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)styryl)benzoic acidCFTR inhibitors
Solubility: Up to 100 mM in DMSO
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage Condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19572075
