Product Name: GSK1120212 (Trametinib) | MEK1/2 inhibitor
Product Description: Trametinib (GSK1120212) is an orally-available, tetrahydropyridopyrimidine-based, allosteric inhibitor of MEK1 and MEK2, with an IC50 of 1.6 and 3.4 nM when using B-Raf as its activator. [1] It is highly selective over broad inhibitory panel of 98 kinasesWeb Site click
Chemical Formula: C26H23FIN5O4
Molecular Weight: 615.39
‘&“CAS NO: 254750-02-2 Emricasan
Purity: 98%
Appearance: White
Chemical Name: N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamideIRE1 inhibitors
Solubility: Up to 10 mM in DMSO
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage Condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22397330
